Pancreatic damage in COVID-19: Why? How?
Int J Clin Pract
; 75(10): e14692, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34331821
ABSTRACT
OBJECT We aimed to evaluate the elevation of amylase and lipase enzymes in coronavirus disease 2019 (COVID-19) patients and their relationship with the severity of COVID-19. METHOD:
In this study, 1378 patients with COVID-19 infection were included. Relation of elevated amylase and lipase levels and comorbidities with the severity of COVID-19 was analysed. The effects of haemodynamic parameters and organ failure on pancreatic enzymes and their relations with prognosis were statistically analysed.RESULTS:
The 1378 patients comprised of 700 (51.8%) men and 678 (%49.2) women. Of all patients, 687 (49.9%) had mild and 691 (50.1%) patients had severe COVID-19 infection. Amylase elevation at different levels occurred in 316 (%23) out of 1378 patients. In these patients, the amylase levels increased one to three times in 261 and three times in 55 patients. Pancreatitis was detected in only six (%1.89) of these patients according to the Atlanta criteria. According to univariate and multivariate analyses, elevated amylase levels were significantly associated with the severity of COVID-19 (odds ratio [OR] 4.37; P < .001). Moreover, diabetes mellitus (DM; OR 1.82; P = .001), kidney failure (OR 5.18; P < .001), liver damage (OR 6.63; P < .001), hypotension (OR 6.86; P < .001) and sepsis (OR 6.20; P = .008) were found to be associated with mortality from COVID-19.CONCLUSION:
Elevated pancreatic enzyme levels in COVID-19 infections are related to the severity of COVID-19 infection and haemodynamic instability. In a similar way to other organs, the pancreas can be affected by severe COVID-19 infection.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Páncreas
/
Pancreatitis
/
COVID-19
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Año:
2021
Tipo del documento:
Article