Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A-dependent bioproduction in rewired Pseudomonas putida.

Kozaeva, Ekaterina; Volkova, Svetlana; Matos, Marta R A; Mezzina, Mariela P; Wulff, Tune; Volke, Daniel C; Nielsen, Lars K; Nikel, Pablo I

Kozaeva, Ekaterina; Volkova, Svetlana; Matos, Marta R A; Mezzina, Mariela P; Wulff, Tune; Volke, Daniel C; Nielsen, Lars K; Nikel, Pablo I.

Kozaeva E; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Volkova S; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Matos MRA; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Mezzina MP; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Wulff T; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Volke DC; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Nielsen LK; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia.
Nikel PI; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark. Electronic address: pabnik@biosustain.dtu.dk.

Metab Eng ; 67: 373-386, 2021 09.

Article en En | MEDLINE | ID: mdl-34343699

Asunto(s)

Pseudomonas putida; Acetilcoenzima A/genética; Acetilcoenzima A/metabolismo; Citrato (si)-Sintasa/genética; Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas; Ingeniería Metabólica; Plásmidos; Pseudomonas putida/genética; Pseudomonas putida/metabolismo

Palabras clave

Acetyl-CoA; CRISPRi; Metabolic engineering; Poly(3-hydroxybutyrate); Pseudomonas putida; Synthetic biology

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pseudomonas putida Tipo de estudio: Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pseudomonas putida Tipo de estudio: Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Article