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Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation.
Truebestein, Linda; Hornegger, Harald; Anrather, Dorothea; Hartl, Markus; Fleming, Kaelin D; Stariha, Jordan T B; Pardon, Els; Steyaert, Jan; Burke, John E; Leonard, Thomas A.
  • Truebestein L; Department of Structural and Computational Biology, Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.
  • Hornegger H; Department of Medical Biochemistry, Medical University of Vienna, 1090 Vienna, Austria.
  • Anrather D; Department of Structural and Computational Biology, Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.
  • Hartl M; Department of Medical Biochemistry, Medical University of Vienna, 1090 Vienna, Austria.
  • Fleming KD; Mass Spectrometry Core Facility, Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.
  • Stariha JTB; Mass Spectrometry Core Facility, Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.
  • Pardon E; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 2Y2, Canada.
  • Steyaert J; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 2Y2, Canada.
  • Burke JE; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium.
  • Leonard TA; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), 1050 Brussels, Belgium.
Proc Natl Acad Sci U S A ; 118(33)2021 08 17.
Article en En | MEDLINE | ID: mdl-34385319
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfatos de Fosfatidilinositol / Proteínas Proto-Oncogénicas c-akt / Piruvato Deshidrogenasa Quinasa Acetil-Transferidora Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfatos de Fosfatidilinositol / Proteínas Proto-Oncogénicas c-akt / Piruvato Deshidrogenasa Quinasa Acetil-Transferidora Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article