Inflammatory state and autism-like behavioral phenotype of offspring induced by maternal exposure to low-dose chemical mixtures during pregnancy in mice.
Zhejiang Da Xue Xue Bao Yi Xue Ban
; 50(3): 279-289, 2021 Jun 25.
Article
en En
| MEDLINE
| ID: mdl-34402257
ABSTRACT
To investigate the effects of maternal exposure to 13 chemicals mixture (CM) during pregnancy on pregnancy outcome and health status of maternal/offspring mice. C57BL/6 pregnant mice were given drinking water containing carbarylâ
dimethoateâ
glyphosateâ
methomyl methyl parathion triadimefon aspartame sodium benzoateâ
calcium disodium ethylene diamine tetra-acetateâ
ethylparaben butylparaben bisphenol A and acacia gum The effects of CM exposure on pregnancy outcome, health status of dams/offspring, levels of circulating inflammatory cytokines in dams/offspring and emotional related behaviors of offspring were evaluated. CM exposure during pregnancy had no significant effect on pregnancy outcome, liver function, body weight of the dams in late pregnancy and uterine/ovarian weight after delivery, however, it led to an increase in maternal serum IFN-γ level ï¼<0.05ï¼. CM exposure during pregnancy had no significant effect on the liver function of offspring, but increased the serum IFN-γ, prefrontal cortex IFN-γ, and TNF-α and hippocampus IFN-γ levels in the offspringï¼all <0.01ï¼. In addition, the offspring of CM group showed significant abnormal emotion-related (autism-like) behaviors in adulthood, especially in male offspring. Low dose CM exposure during pregnancy may induce inflammation status in dams/offspring, and lead to autism-like behaviors in offspring, indicating the potential effects of low dose CM exposure on human maternal and infant health.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Trastorno Autístico
Límite:
Adult
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Animals
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Año:
2021
Tipo del documento:
Article