Conversion of Primary Alcohols and Butadiene to Branched Ketones via Merged Transfer Hydrogenative Carbonyl Addition-Redox Isomerization Catalyzed by Rhodium.
J Am Chem Soc
; 143(34): 13507-13512, 2021 09 01.
Article
en En
| MEDLINE
| ID: mdl-34415159
ABSTRACT
The first examples of rhodium-catalyzed carbonyl addition via hydrogen autotransfer are described, as illustrated in tandem butadiene-mediated carbonyl addition-redox isomerizations that directly convert primary alcohols to isobutyl ketones. Related reductive coupling-redox isomerizations of aldehyde reactants mediated by sodium formate also are reported. A double-labeling crossover experiment reveals that the rhodium alkoxide obtained upon carbonyl addition enacts redox isomerization without dissociation of rhodium at any intervening stage.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Rodio
/
Butadienos
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Alcoholes
/
Cetonas
Idioma:
En
Año:
2021
Tipo del documento:
Article