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Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
Watanabe, Akiko; Ishizuka, Tomoko; Yamada, Makiko; Igawa, Yoshiyuki; Shimizu, Takako; Ishizuka, Hitoshi.
  • Watanabe A; Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan. watanabe.akiko.mi@daiichisankyo.co.jp.
  • Ishizuka T; Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Yamada M; Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Igawa Y; Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Shimizu T; Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
  • Ishizuka H; Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Eur J Clin Pharmacol ; 78(1): 65-73, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34415382
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirroles / Sulfonas / Fallo Hepático / Inductores del Citocromo P-450 CYP3A / Inhibidores del Citocromo P-450 CYP3A / Antihipertensivos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans País como asunto: Asia Idioma: En Año: 2022 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirroles / Sulfonas / Fallo Hepático / Inductores del Citocromo P-450 CYP3A / Inhibidores del Citocromo P-450 CYP3A / Antihipertensivos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans País como asunto: Asia Idioma: En Año: 2022 Tipo del documento: Article