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Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1.
Lv, Xiaohui; Zhou, Honghong; Hu, Kai; Lin, Ling; Yang, Yongqiang; Li, Longjiang; Tang, Li; Huang, Jiayi; Shen, Yi; Jiang, Rong; Wan, Jingyuan; Zhang, Li.
  • Lv X; Department of Pathophysiology, Chongqing Medical University, Chongqing, China; Laboratory of Stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China.
  • Zhou H; Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
  • Hu K; Laboratory of Stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China; Department of Histology and Embryology, Chongqing Medical University, Chongqing, China.
  • Lin L; Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
  • Yang Y; Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
  • Li L; Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
  • Tang L; Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
  • Huang J; Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
  • Shen Y; Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
  • Jiang R; Laboratory of Stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China.
  • Wan J; Department of Pharmacology, Chongqing Medical University, Chongqing, China. Electronic address: jywan@cqmu.edu.cn.
  • Zhang L; Department of Pathophysiology, Chongqing Medical University, Chongqing, China; Laboratory of Stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China. Electronic address: zhangli@cqmu.edu.cn.
Pharmacol Res ; 172: 105838, 2021 10.
Article en En | MEDLINE | ID: mdl-34425230
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piruvato Quinasa / Proteína Quinasa CDC2 / Ácido Pirúvico / Hepatopatías Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piruvato Quinasa / Proteína Quinasa CDC2 / Ácido Pirúvico / Hepatopatías Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article