Chimeric Flaviviral RNA-siRNA Molecules Resist Degradation by The Exoribonuclease Xrn1 and Trigger Gene Silencing in Mammalian Cells.

Harvey, Cressida; Klassa, Sven; Finol, Esteban; Hall, Jonathan; Hill, Alyssa C

Harvey, Cressida; Klassa, Sven; Finol, Esteban; Hall, Jonathan; Hill, Alyssa C.

Harvey C; Department of Biology, ETH Zürich, Wolfgang-Pauli-Strasse 27, 8093, Zürich, Switzerland.
Klassa S; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093, Zürich, Switzerland.
Finol E; Department of Biology, ETH Zürich, Wolfgang-Pauli-Strasse 27, 8093, Zürich, Switzerland.
Hall J; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093, Zürich, Switzerland.
Hill AC; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093, Zürich, Switzerland.

Chembiochem ; 22(21): 3099-3106, 2021 11 03.

Article en En | MEDLINE | ID: mdl-34431199

Asunto(s)

Exorribonucleasas/metabolismo; Flavivirus/metabolismo; Silenciador del Gen; ARN Interferente Pequeño/metabolismo; ARN Viral/metabolismo; Exorribonucleasas/química; Flavivirus/química; Células HEK293; Humanos; ARN Interferente Pequeño/química; ARN Interferente Pequeño/genética; ARN Viral/química; ARN Viral/genética

Palabras clave

RNA nanotechnology; exonuclease-resistant RNA; self-assembly; small interfering RNA

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ARN Viral / Silenciador del Gen / ARN Interferente Pequeño / Exorribonucleasas / Flavivirus Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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