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Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity.
Cindy Yang, S Y; Lien, Scott C; Wang, Ben X; Clouthier, Derek L; Hanna, Youstina; Cirlan, Iulia; Zhu, Kelsey; Bruce, Jeffrey P; El Ghamrasni, Samah; Iafolla, Marco A J; Oliva, Marc; Hansen, Aaron R; Spreafico, Anna; Bedard, Philippe L; Lheureux, Stephanie; Razak, Albiruni; Speers, Vanessa; Berman, Hal K; Aleshin, Alexey; Haibe-Kains, Benjamin; Brooks, David G; McGaha, Tracy L; Butler, Marcus O; Bratman, Scott V; Ohashi, Pamela S; Siu, Lillian L; Pugh, Trevor J.
  • Cindy Yang SY; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Lien SC; Department of Immunology, University of Toronto, Toronto, ON, Canada.
  • Wang BX; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Clouthier DL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Hanna Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Cirlan I; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Zhu K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Bruce JP; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • El Ghamrasni S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Iafolla MAJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Oliva M; Division of Medical Oncology & Haematology, Princess Margaret Cancer Centre, University of Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Hansen AR; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Spreafico A; Division of Medical Oncology & Haematology, Princess Margaret Cancer Centre, University of Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Bedard PL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Lheureux S; Division of Medical Oncology & Haematology, Princess Margaret Cancer Centre, University of Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Razak A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Speers V; Division of Medical Oncology & Haematology, Princess Margaret Cancer Centre, University of Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Berman HK; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Aleshin A; Division of Medical Oncology & Haematology, Princess Margaret Cancer Centre, University of Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Haibe-Kains B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Brooks DG; Division of Medical Oncology & Haematology, Princess Margaret Cancer Centre, University of Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • McGaha TL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Butler MO; Division of Medical Oncology & Haematology, Princess Margaret Cancer Centre, University of Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Bratman SV; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Ohashi PS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Siu LL; Natera, Inc., San Carlos, CA, USA.
  • Pugh TJ; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Nat Commun ; 12(1): 5137, 2021 08 26.
Article en En | MEDLINE | ID: mdl-34446728
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / ADN Tumoral Circulante / Neoplasias / Antineoplásicos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / ADN Tumoral Circulante / Neoplasias / Antineoplásicos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article