Enzymatic modular assembly of hybrid Lewis antigens.
Org Biomol Chem
; 19(37): 8041-8048, 2021 09 29.
Article
en En
| MEDLINE
| ID: mdl-34473187
ABSTRACT
The enzymatic synthesis of hybrid Lewis antigens including KH-1 (Lewis y-Lewis x-Lactose, Ley-Lex-Lac), Lewis a-Lewis x-Lactose (Lea-Lex-Lac), and Lewis b-Lewis x-Lactose (Leb-Lex-Lac) has been achieved using a facile enzymatic modular assembly strategy. Starting from a readily available tetrasaccharide, 3 complex hybrid Lewis antigens were achieved in over 40% total yields in less than 5 linear steps of sequential enzymatic glycosylation using 6 enzyme modules. The regio-selective fucosylation was achieved by simply controlling the donor-acceptor ratio. This strategy provides an easy access to these biologically important complex hybrid Lewis antigens at preparative scales.
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1
Banco de datos:
MEDLINE
Asunto principal:
Antígenos del Grupo Sanguíneo de Lewis
Idioma:
En
Año:
2021
Tipo del documento:
Article