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Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Bowen, Nicole E; Temple, Joshua; Shepard, Caitlin; Oo, Adrian; Arizaga, Fidel; Kapoor-Vazirani, Priya; Persaud, Mirjana; Yu, Corey H; Kim, Dong-Hyun; Schinazi, Raymond F; Ivanov, Dmitri N; Diaz-Griffero, Felipe; Yu, David S; Xiong, Yong; Kim, Baek.
  • Bowen NE; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Temple J; Department of Molecular Biophysics and Biochemistry, School of Medicine, Yale University, New Haven, Connecticut, USA.
  • Shepard C; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Oo A; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Arizaga F; Department of Molecular Biophysics and Biochemistry, School of Medicine, Yale University, New Haven, Connecticut, USA.
  • Kapoor-Vazirani P; Department of Radiation Oncology, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Persaud M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Yu CH; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA.
  • Kim DH; School of Pharmacy, Kyung-Hee University, Seoul, South Korea.
  • Schinazi RF; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Ivanov DN; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA.
  • Diaz-Griffero F; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Yu DS; Department of Radiation Oncology, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Xiong Y; Department of Molecular Biophysics and Biochemistry, School of Medicine, Yale University, New Haven, Connecticut, USA. Electronic address: yong.xiong@yale.edu.
  • Kim B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA; Children's Healthcare of Atlanta, Atlanta, Georgia, USA. Electronic address: baek.kim@emory.edu.
J Biol Chem ; 297(4): 101170, 2021 10.
Article en En | MEDLINE | ID: mdl-34492268
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia / Neoplasias del Colon / Mutación Missense / Proteína 1 que Contiene Dominios SAM y HD / Proteínas de Neoplasias Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia / Neoplasias del Colon / Mutación Missense / Proteína 1 que Contiene Dominios SAM y HD / Proteínas de Neoplasias Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article