A three-antigen Plasmodium falciparum DNA prime-Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults.

Sklar, Marvin J; Maiolatesi, Santina; Patterson, Noelle; Sedegah, Martha; Limbach, Keith; Teneza-Mora, Nimfa; Chuang, Ilin; Hollis-Perry, K Monique; Banania, Jo Glenna; Guzman, Ivelese; Ganeshan, Harini; Reyes, Sharina; Hollingdale, Michael R; Wong, Mimi; Lindstrom, Ashley; Reyes, Anatalio; Alcorta, Yolanda; Garver, Lindsey; Bankard, Kelli; Belmonte, Arnel; Belmonte, Maria; Huang, Jun; Gowda, Kalpana; Inoue, Sandra; Velasco, Rachel; Bergmann-Leitner, Elke; Hutter, Jack; Lee, Tida; Adams, Nehkonti; Chaudhury, Sidhartha; Hunt, Devin; Tamminga, Cindy; Berrie, Eleanor; Bellamy, Duncan; Bittaye, Mustapha; Ewer, Katie; Diggs, Carter; Soisson, Lorraine A; Lawrie, Alison; Hill, Adrian; Richie, Thomas L; Villasante, Eileen; Epstein, Judith E; Duplessis, Christopher A

Sklar, Marvin J; Maiolatesi, Santina; Patterson, Noelle; Sedegah, Martha; Limbach, Keith; Teneza-Mora, Nimfa; Chuang, Ilin; Hollis-Perry, K Monique; Banania, Jo Glenna; Guzman, Ivelese; Ganeshan, Harini; Reyes, Sharina; Hollingdale, Michael R; Wong, Mimi; Lindstrom, Ashley; Reyes, Anatalio; Alcorta, Yolanda; Garver, Lindsey; Bankard, Kelli; Belmonte, Arnel; Belmonte, Maria; Huang, Jun; Gowda, Kalpana; Inoue, Sandra; Velasco, Rachel; Bergmann-Leitner, Elke; Hutter, Jack; Lee, Tida; Adams, Nehkonti; Chaudhury, Sidhartha; Hunt, Devin; Tamminga, Cindy; Berrie, Eleanor; Bellamy, Duncan; Bittaye, Mustapha; Ewer, Katie; Diggs, Carter; Soisson, Lorraine A; Lawrie, Alison; Hill, Adrian; Richie, Thomas L; Villasante, Eileen; Epstein, Judith E; Duplessis, Christopher A.

Sklar MJ; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Maiolatesi S; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Patterson N; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Sedegah M; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Limbach K; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Teneza-Mora N; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Chuang I; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Hollis-Perry KM; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Banania JG; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Guzman I; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Ganeshan H; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Reyes S; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Hollingdale MR; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Wong M; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Lindstrom A; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Reyes A; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Alcorta Y; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Garver L; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Bankard K; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Belmonte A; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Belmonte M; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Huang J; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Gowda K; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Inoue S; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Velasco R; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Bergmann-Leitner E; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Hutter J; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Lee T; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Adams N; Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Chaudhury S; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Hunt D; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Tamminga C; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Berrie E; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Bellamy D; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Bittaye M; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Ewer K; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Diggs C; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Soisson LA; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Lawrie A; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Hill A; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Richie TL; Naval Medical Research Center, Silver Spring, Maryland, United States of America.
Villasante E; Henry M. Jackson Foundation, Bethesda, Maryland, United States of America.
Epstein JE; Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Duplessis CA; Naval Medical Research Center, Silver Spring, Maryland, United States of America.

PLoS One ; 16(9): e0256980, 2021.

Article en En | MEDLINE | ID: mdl-34495988

Asunto(s)

Vacunas contra el Adenovirus/inmunología; Adenovirus de los Simios/inmunología; Antígenos de Protozoos/inmunología; ADN Protozoario/inmunología; ADN Recombinante/inmunología; Inmunización Secundaria/métodos; Vacunas contra la Malaria/inmunología; Malaria Falciparum/prevención & control; Proteínas de la Membrana/inmunología; Plasmodium falciparum/inmunología; Proteínas Protozoarias/inmunología; Vacunas de ADN/inmunología; Vacunas contra el Adenovirus/administración & dosificación; Vacunas contra el Adenovirus/efectos adversos; Adenovirus de los Simios/genética; Adulto; Antígenos de Protozoos/genética; Linfocitos T CD8-positivos/inmunología; ADN Protozoario/genética; Epítopos/genética; Epítopos/inmunología; Femenino; Vectores Genéticos/administración & dosificación; Vectores Genéticos/inmunología; Voluntarios Sanos; Humanos; Inmunogenicidad Vacunal/inmunología; Vacunas contra la Malaria/administración & dosificación; Vacunas contra la Malaria/efectos adversos; Malaria Falciparum/inmunología; Malaria Falciparum/parasitología; Masculino; Proteínas de la Membrana/genética; Proteínas Protozoarias/genética; Resultado del Tratamiento; Vacunas de ADN/administración & dosificación; Vacunas de ADN/efectos adversos; Adulto Joven

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / ADN Recombinante / Proteínas Protozoarias / Adenovirus de los Simios / ADN Protozoario / Inmunización Secundaria / Malaria Falciparum / Vacunas contra la Malaria / Vacunas de ADN / Vacunas contra el Adenovirus Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article

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