Targeting Human Papillomavirus-Associated Cancer by Oncoprotein-Specific Recombinant Antibodies.
Int J Mol Sci
; 22(17)2021 Aug 24.
Article
en En
| MEDLINE
| ID: mdl-34502053
ABSTRACT
In recent decades, recombinant antibodies against specific antigens have shown great promise for the therapy of infectious diseases and cancer. Human papillomaviruses (HPVs) are involved in the development of around 5% of all human cancers and HPV16 is the high-risk genotype with the highest prevalence worldwide, playing a dominant role in all HPV-associated cancers. Here, we describe the main biological activities of the HPV16 E6, E7, and E5 oncoproteins, which are involved in the subversion of important regulatory pathways directly associated with all known hallmarks of cancer. We then review the state of art of the recombinant antibodies targeted to HPV oncoproteins developed so far in different formats, and outline their mechanisms of action. We describe the advantages of a possible antibody-based therapy against the HPV-associated lesions and discuss the critical issue of delivery to tumour cells, which must be addressed in order to achieve the desired translation of the antibodies from the laboratory to the clinic.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Anticuerpos de Dominio Único
/
Anticuerpos Antivirales
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Neoplasias
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article