Lung dendritic cells migrate to the spleen to prime long-lived TCF1hi memory CD8+ T cell precursors after influenza infection.
Sci Immunol
; 6(63): eabg6895, 2021 Sep 10.
Article
en En
| MEDLINE
| ID: mdl-34516781
ABSTRACT
CD8+ T cell responses to pulmonary challenges are primed by lung migratory dendritic cells (mDCs), which capture antigens in the lungs and migrate to the lung-draining mediastinal lymph node (med-LN) to activate T cells. The lungs and the spleen are not connected by the lymphatic vasculature. Thus, the current paradigm suggests that, in response to respiratory virus infections that are restricted to the respiratory tract, priming of T cell responses by lung mDCs takes place entirely in the med-LN. Our results challenge this "LN-centric" paradigm by demonstrating that, during influenza virus infection, lung mDCs egress the med-LN and traffic to the spleen, where they prime influenza-specific CD8+ T cells. CD8+ T cells primed in the spleen are transcriptionally distinct and have enhanced ability to differentiate into long-lived memory cells compared with med-LNprimed counterparts. Thus, our data identify a lung mDC trafficking pathway that connects the lungs with the spleen.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bazo
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Infecciones por Orthomyxoviridae
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Linfocitos T CD8-positivos
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Factor Nuclear 1-alfa del Hepatocito
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Pulmón
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article