Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4 nanoparticles.
Nanomedicine (Lond)
; 16(24): 2189-2206, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34533056
ABSTRACT
Background:
We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP) bare, citrate-coated and bovine serum albumin-coated MNPs.Methods:
We employed the ACB system, gel electrophoresis and mass spectrometry analysis.Results:
Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied.Conclusion:
These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.Palabras clave
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1
Banco de datos:
MEDLINE
Asunto principal:
Nanopartículas de Magnetita
/
Corona de Proteínas
Idioma:
En
Año:
2021
Tipo del documento:
Article