Acute and subacute toxicity evaluation of hydroalcoholic extract from the stem bark of Bois Bande (Parinari campestris Aubl.1772) in rats.
BMC Pharmacol Toxicol
; 22(1): 51, 2021 09 25.
Article
en En
| MEDLINE
| ID: mdl-34563262
ABSTRACT
INTRODUCTION:
The bark of Bois Bande (Parinari campestris) is a popular aphrodisiac in the Caribbean that has been traditionally used for many years to restore sexual vitality, increase sperm count, and treat erectile dysfunction, without valid scientific data. Acute and 28-day subacute toxicity studies were conducted to evaluate the safety of the hydroalcoholic extract of P.campestris bark and to find a safe dose for human use in conventional medicine.METHODS:
The acute toxicity study used a single oral dose of P.campestris extract at four separate doses, 5, 50, 300, and 2,000 mg/kg, and was seen for 14 days, while the subacute toxicity study used a daily oral dose of P.campestris extract at 3 different doses, 100, 300, and 1000 mg/kg/day for 28 days.RESULTS:
The LD50 of P.campestris extract was found to be greater than 2000 mg/kg in the acute toxicity study. P.campestris extract did not show toxicity at 1000 mg/kg/day in subacute toxicity trial; NOAEL was 1000 mg/kg/day in rats. However, the body weight was increased in males.CONCLUSION:
In conclusion, 1000 mg/kg P.campestris extract can be considered safe and non-toxic in males.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Malpighiales
Límite:
Animals
Idioma:
En
Año:
2021
Tipo del documento:
Article