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Blood and Stool Arsenic Levels Are Decisive for Diagnosing Children's Functional Gastrointestinal Disease (FGD).
Bilici, Namik; Dogan, Erkan; Sevinç, Eylem; Sevinç, Nergiz; Akinci, Gülsema; Musmul, Ahmet; Cengiz, Mustafa; Sahin, Ilknur Kulcanay; Aslanipour, Behnaz; Ayhanci, Adnan.
  • Bilici N; Faculty of Medicine Department of Medical Pharmacology, Karabuk University, Karabuk, Turkey.
  • Dogan E; Faculty of Medicine Department of Child Health and Diseases, Karabük University, Karabuk, Turkey.
  • Sevinç E; Faculty of Medicine Department of Child Health and Diseases, Karabük University, Karabuk, Turkey.
  • Sevinç N; Faculty of Medicine Department of Public Health, Karabuk University, Karabuk, Turkey.
  • Akinci G; Havran State Hospital, Balikesir, Turkey.
  • Musmul A; Department of Medical Services and Techniques Medical Documentation and Secretariat Program, ESOGU Vocational School of Health Services, Eskisehir, Turkey.
  • Cengiz M; Department of Elementary Education, Faculty of Education, Siirt University, Siirt, Turkey. m.cengiz@siirt.edu.tr.
  • Sahin IK; Vocational School of Health Services, Kirikkale University, Kirikkale, Turkey.
  • Aslanipour B; Department of Bioengineering, Faculty of Engineering, Ege University, Izmir, Turkey.
  • Ayhanci A; Faculty of Arts and Science, Department of Biology, Eskisehir Osmangazi University, Eskisehir, Turkey.
Biol Trace Elem Res ; 200(7): 3050-3059, 2022 Jul.
Article en En | MEDLINE | ID: mdl-34564832
ABSTRACT
Pediatric gastroenteritis is a potentially fatal disease that accounts for 10% of childhood deaths. The main risk is environmental factors and nutrition. Arsenic (As) is commonly found in the earth's crust. As is an essential element that can form many organic compounds. In children, it causes diarrhea, gums, tongue lesions, diabetes, conjunctivitis, ocular opacity, and impaired immune response. It also causes low growth, mental retardation, and neurological problems. It is also known as the cause of many cancers that originate at an early age. Regionally, there is an iron and steel industry for almost a century. According to the Rome IV criteria, the blood and stools of 50 children aged 6-18 years, male and female, living in our province with functional gastrointestinal disease (FGD), were screened for As, and compared with the Healthy group (control) of 30 children. The results were evaluated with the Mann-Whitney Rank Sum Test. When blood and stool As values in males were compared with control samples, a high level of significance (p = 0.001) was found between both blood and stool As values in sick males and the control group (p < 0.005). In females, blood and stool As median values were also highly significant when compared with the control group (p = 0.001). According to these data, when the sick children (children with male and female gender) are compared with the healthy ones, the difference is highly significant (p < 0.005). High blood As levels in children indicate environmental pollution. It can be said that blood As levels are high as a result of food, water, and inhaler exposure. The presence of a high level of significant difference in stool means that the amount of As is high in the foods consumed daily. High levels of As are in blood and stools; It was evaluated that FGD could be the cause of nausea, diarrhea, vomiting, and colic. The increase in blood and stool As values due to environmental pollution is an important reason for FGD. For diseases of uncertain cause (such as FGD) resulting from chronic As exposure, blood and especially stool As values are more significant than urinary As levels. In conclusion, As a diagnostic criterion, it was concluded that blood and stool As values are an important marker in children with functional abdominal pain with other metals.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arsénico / Enfermedades Gastrointestinales Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arsénico / Enfermedades Gastrointestinales Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Año: 2022 Tipo del documento: Article