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Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians.
Manning, Jessica; Zaidi, Irfan; Lon, Chanthap; Rosas, Luz Angela; Park, Jae-Keun; Ponce, Aiyana; Bohl, Jennifer; Chea, Sophana; Karkanitsa, Maria; Sreng, Sokunthea; Rekol, Huy; Chour, Char Meng; Esposito, Dominic; Taubenberger, Jeffery K; Memoli, Matthew J; Sadtler, Kaitlyn; Duffy, Patrick E; Oliveira, Fabiano.
  • Manning J; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Zaidi I; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Lon C; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Rosas LA; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Park JK; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Ponce A; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Bohl J; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Chea S; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
  • Sreng S; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
  • Rekol H; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
  • Chour CM; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
  • Esposito D; Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Taubenberger JK; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Memoli MJ; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Sadtler K; National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA.
  • Duffy PE; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Oliveira F; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
medRxiv ; 2021 Sep 28.
Article en En | MEDLINE | ID: mdl-34611671
ABSTRACT
Greater Mekong inhabitants are exposed to pathogens, zoonotic and otherwise, that may influence SARS-CoV-2 seroreactivity. A pre-pandemic (2005 to 2011) serosurvey of from 528 malaria-experienced Cambodians demonstrated higher-than-expected (up to 13.8 %) positivity of non-neutralizing IgG to SARS-CoV-2 spike and RBD antigens. These findings have implications for interpreting large-scale serosurveys. ARTICLE SUMMARY LINE In the pre-COVID19 pandemic years of 2005 to 2011, malaria experienced Cambodians from rural settings had higher-than-expected seroreactivity to SARS-CoV-2 spike and receptor binding domain proteins.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article