Seizure Deterioration with Increased Levetiracetam Blood Concentration during the Postpartum Period in Refractory Temporal Lobe Epilepsy.
Intern Med
; 61(8): 1237-1240, 2022 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-34615824
ABSTRACT
We evaluated a 39-year-old pregnant woman with right temporal lobe epilepsy. During the second trimester, seizure deterioration was responsive to an increased daily dose of levetiracetam (LEV). However, immediately after delivery, new non-habitual seizures emerged along with a sharply increased LEV concentration. The frequency of habitual seizures also slightly increased. The non-habitual seizures completely disappeared, and the frequency of the habitual seizures improved to the baseline level after the LEV dosage was reduced. Thus, a paradoxical effect of an increased LEV blood concentration was assumed to be a potential cause of these events. Peripartum pharmacokinetic fluctuations in LEV levels should be monitored carefully.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piracetam
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Epilepsia del Lóbulo Temporal
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Año:
2022
Tipo del documento:
Article