JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition.
J Allergy Clin Immunol
; 148(4): 911-925, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34625141
ABSTRACT
Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-STAT) pathway has become recognized as a central mediator of widespread and varied human physiological processes. The field of JAK-STAT biology, particularly its clinical relevance, continues to be shaped by 2 important advances. First, the increased use of genomic sequencing has led to the discovery of novel clinical syndromes caused by mutations in JAK and STAT genes. This has provided insights regarding the consequences of aberrant JAK-STAT signaling for immunity, lymphoproliferation, and malignancy. In addition, since the approval of ruxolitinib and tofacitinib, the therapeutic use of JAK inhibitors (jakinibs) has expanded to include a large spectrum of diseases. Efficacy and safety data from over a decade of clinical studies have provided additional mechanistic insights while improving the care of patients with inflammatory and neoplastic conditions. This review discusses major advances in the field, focusing on updates in genetic diseases and in studies of clinical jakinibs in human disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción STAT
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Quinasas Janus
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Inhibidores de las Cinasas Janus
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Enfermedades Genéticas Congénitas
Límite:
Animals
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article