Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study.
Eur J Pediatr
; 181(3): 1263-1267, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-34643785
ABSTRACT
Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected; 10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion:
Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Vitamina D
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Humans
País como asunto:
Africa
Idioma:
En
Año:
2022
Tipo del documento:
Article