Your browser doesn't support javascript.
loading
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious ß-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.
Machauer, Rainer; Lueoend, Rainer; Hurth, Konstanze; Veenstra, Siem J; Rueeger, Heinrich; Voegtle, Markus; Tintelnot-Blomley, Marina; Rondeau, Jean-Michel; Jacobson, Laura H; Laue, Grit; Beltz, Karen; Neumann, Ulf.
  • Machauer R; Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Lueoend R; Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Hurth K; Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Veenstra SJ; Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Rueeger H; Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Voegtle M; Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Tintelnot-Blomley M; Global Discovery Chemistry, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Rondeau JM; Chemical Biology and Therapeutics, Structural Biology Platform, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Jacobson LH; Department of Neuroscience, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Laue G; Pharmacokinetic-Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Beltz K; Pharmacokinetic-Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  • Neumann U; Department of Neuroscience, Novartis Pharma AG, CH-4056 Basel, Switzerland.
J Med Chem ; 64(20): 15262-15279, 2021 10 28.
Article en En | MEDLINE | ID: mdl-34648711
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxazinas / Ácido Aspártico Endopeptidasas / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Descubrimiento de Drogas / Enfermedad de Alzheimer Límite: Animals / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxazinas / Ácido Aspártico Endopeptidasas / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Descubrimiento de Drogas / Enfermedad de Alzheimer Límite: Animals / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article