Glucose/insulin metabolism and vitamin D in women with recurrent pregnancy loss.
Am J Reprod Immunol
; 87(1): e13505, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34687115
ABSTRACT
OBJECTIVE:
Glucose/insulin metabolism has been related to recurrent pregnancy loss (RPL) through mechanisms not really clarified. Also, vitamin D deficiency seems to be associated to RPL. The purpose of our study was to evaluate the correlation between glucose/insulin metabolism parameters and vitamin D levels in women with history of RPL. STUDYDESIGN:
Observational retrospective study on RPL women. The correlation among vitamin D levels and fasting glucose (FG), fasting insulin (FI), Homeostatic model assessment of insulin resistance (HOMA-IR) index, area under glucose curve (AUC-Glyc) and area under insulin curve (AUC-Ins), was evaluated.RESULTS:
One-hundred and twenty-seven RPL women were classified into three subgroups (0-1-2) according to the levels of FI. We found a statistically significant linear Pearson correlation between FI and HOMA-IR (r = .840; P = .001). An, inverse, but non-significant correlation both between vitamin D and FI (R = -.202, ns) and vitamin D levels and AUC-Ins (R = -.288, ns) was observed. The variables vitamin D, HOMA-IR and AUC-Ins were statistically significant in the considered subgroups (Vitamin D ANOVA + Bonferroni test 0 vs. 1; P = .001; 0 vs. 2; P = .010; 1 vs. 2; P = .657; HOMA-IR ANOVA + Bonferroni test 0 vs. 1; P = .014; 0 vs. 2; P = .001; 1 vs. 2; P = .001; AUC-Ins ANOVA + Bonferroni test 0 vs. 1; P = .010; 0 vs. 2; P = .206; 1 vs. 2; P = .980).CONCLUSIONS:
Vitamin D might play additional roles in the pathogenesis of RPL, beyond its well known immunomodulatory role.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Glucemia
/
Resistencia a la Insulina
/
Aborto Habitual
/
Insulina
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
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Middle aged
/
Pregnancy
Idioma:
En
Año:
2022
Tipo del documento:
Article