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Prediction of lateral lymph node metastasis using OSNA method for mesorectal lymph nodes in low rectal cancer: A prospective study by the Kanagawa Yokohama Colorectal Cancer Study Group (KYCC1801).
Numata, Masakatsu; Shiozawa, Manabu; Godai, Teni; Kazama, Keisuke; Okamoto, Hironao; Kato, Aya; Katayama, Yusuke; Sato, Sumito; Sugano, Nobuhiro; Kohmura, Takashi; Higuchi, Akio; Saito, Kentaro; Iguchi, Kenta; Atsumi, Yosuke; Aoyama, Toru; Tamagawa, Hiroshi; Mushiake, Hiroyuki; Saeki, Hiroyuki; Yukawa, Norio; Taguri, Masataka; Sato, Maho; Rino, Yasushi.
  • Numata M; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Shiozawa M; Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Godai T; Department of Surgery, Fujisawa Shonandai Hospital, Fujisawa, Kanagawa, Japan.
  • Kazama K; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Okamoto H; Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Kato A; Department of Surgery, Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan.
  • Katayama Y; Department of Surgery, Hadano Red Cross Hospital, Hadano, Kanagawa, Japan.
  • Sato S; Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Sugano N; Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Kohmura T; Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Higuchi A; Department of Surgery, Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan.
  • Saito K; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Iguchi K; Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Atsumi Y; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Aoyama T; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Tamagawa H; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Mushiake H; Department of Surgery, Saiseikai Yokohama Nanbu Hospital, Yokohama, Kanagawa, Japan.
  • Saeki H; Department of Surgery, Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan.
  • Yukawa N; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Taguri M; Department of Biostatistics, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Sato M; Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Rino Y; Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.
J Surg Oncol ; 125(3): 457-464, 2022 Mar.
Article en En | MEDLINE | ID: mdl-34704609
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Contrary to the Japanese guidelines recommendations regarding lateral lymph node dissection (LatLND) for rectal cancer, its omission is common in clinical practice without reliable omission criteria. Negative pathological mesorectal lymph node metastasis (MesLNM) is reportedly highly correlated with negative pathological lateral lymph node metastasis (p-LatLNM); however, this cannot be used as a criterion because pathological features are revealed postoperatively. Herein, we prospectively evaluated the negative predictive value (NPV) of MesLNM diagnosed via the one-step nucleic acid amplification (OSNA) method for p-LatLNM.

METHODS:

This prospective study was conducted at a single academic study group in Japan. The key eligibility criterion was mid-to-low rectal cancer planned to be treated using mesorectal excision with LatLND. According to the study protocol, the OSNA method was considered useful if the point estimate of the NPV exceeded 95%.

RESULTS:

Preoperative case registration was conducted between 2018 and 2020; 34 patients were registered. Among these, 16 were negative for OSNA-MesLNM, and negative p-LatLNM was confirmed in all cases. The point estimate of the NPV was 100%, with the 95% confidence interval ranging from 79.4% to 100.0%.

CONCLUSIONS:

The OSNA method is useful in selecting patients in whom LatLND can be omitted in real-world clinical practice.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias del Recto / Carcinoma Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como asunto: Asia Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias del Recto / Carcinoma Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como asunto: Asia Idioma: En Año: 2022 Tipo del documento: Article