Integration of SARS-CoV-2 RNA in infected human cells by retrotransposons: an unlikely hypothesis and old viral relationships.
Retrovirology
; 18(1): 34, 2021 10 29.
Article
en En
| MEDLINE
| ID: mdl-34715873
ABSTRACT
Zhang et al. (Proc Natl Acad Sci 118e2105968118, 2021) recently reported that SARS-CoV-2 RNA can be retrotranscribed and integrated into the DNA of human cells by the L1 retrotransposon machinery. This phenomenon could cause persistence of viral sequences in patients and may explain the prolonged PCR-positivity of SARS-CoV-2 infected patients, even long after the phase of active virus replication has ended. This commentary does critically review the available data on this topic and discusses them in the context of findings made for other exogenous viruses and ancestral endogenous retroviral elements.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Retroelementos
/
COVID-19
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article