Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.

Wang, Xin; Feng, Yan-Lian; Zhao, Xiao-Yu; An, Ran; Cao, Chun; Guo, Meng-Bi; Zhang, Rui; Wang, Yuan-Xin; Hou, Zhuang; Guo, Chun

Wang, Xin; Feng, Yan-Lian; Zhao, Xiao-Yu; An, Ran; Cao, Chun; Guo, Meng-Bi; Zhang, Rui; Wang, Yuan-Xin; Hou, Zhuang; Guo, Chun.

Wang X; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Feng YL; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhao XY; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
An R; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Cao C; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Guo MB; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang R; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang YX; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Hou Z; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: houzhuang8@sina.com.
Guo C; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: gc_66888@163.com.

Bioorg Med Chem Lett ; 53: 128420, 2021 12 01.

Article en En | MEDLINE | ID: mdl-34728369

Asunto(s)

Aminas/farmacología; Carbohidratos/farmacología; Anhidrasa Carbónica II/antagonistas & inhibidores; Inhibidores de Anhidrasa Carbónica/farmacología; Descubrimiento de Drogas; Sulfonamidas/farmacología; Aminas/química; Animales; Carbohidratos/química; Anhidrasa Carbónica II/metabolismo; Inhibidores de Anhidrasa Carbónica/síntesis química; Inhibidores de Anhidrasa Carbónica/química; Línea Celular; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Humanos; Isoenzimas/antagonistas & inhibidores; Isoenzimas/metabolismo; Ratones; Microsomas Hepáticos/química; Microsomas Hepáticos/metabolismo; Estructura Molecular; Relación Estructura-Actividad; Sulfonamidas/síntesis química; Sulfonamidas/química

Palabras clave

Aminosaccharide; CA inhibitors; Carbonic anhydrase II; Carzenide

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Carbohidratos / Inhibidores de Anhidrasa Carbónica / Anhidrasa Carbónica II / Descubrimiento de Drogas / Aminas Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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