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SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Jensen-Pergakes, Kristen; Tatlock, John; Maegley, Karen A; McAlpine, Indrawan J; McTigue, Michele; Xie, Tao; Dillon, Christopher P; Wang, Yuli; Yamazaki, Shinji; Spiegel, Noah; Shi, Manli; Nemeth, Amy; Miller, Natalie; Hendrickson, Eleanore; Lam, Hieu; Sherrill, John; Chung, Chi-Yeh; McMillan, Elizabeth A; Bryant, Shannon Karlicek; Palde, Prakash; Braganza, John; Brooun, Alexei; Deng, Ya-Li; Goshtasbi, Vesta; Kephart, Susan E; Kumpf, Robert A; Liu, Wei; Patman, Ryan L; Rui, Eugene; Scales, Stephanie; Tran-Dube, Michelle; Wang, Fen; Wythes, Martin; Paul, Thomas A.
  • Jensen-Pergakes K; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Tatlock J; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Maegley KA; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • McAlpine IJ; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • McTigue M; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Xie T; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Dillon CP; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Wang Y; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Yamazaki S; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., San Diego, California.
  • Spiegel N; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Shi M; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Nemeth A; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Miller N; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Hendrickson E; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Lam H; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Sherrill J; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Chung CY; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • McMillan EA; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Bryant SK; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Palde P; Oncology Research Division, Pfizer Inc.; San Diego, California.
  • Braganza J; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Brooun A; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Deng YL; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Goshtasbi V; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Kephart SE; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Kumpf RA; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Liu W; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Patman RL; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Rui E; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Scales S; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Tran-Dube M; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Wang F; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Wythes M; Oncology Medicinal Chemistry, Pfizer Inc.; San Diego, California.
  • Paul TA; Oncology Research Division, Pfizer Inc.; San Diego, California. Thomas.A.Paul@pfizer.com.
Mol Cancer Ther ; 21(1): 3-15, 2022 01.
Article en En | MEDLINE | ID: mdl-34737197
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / S-Adenosilmetionina / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / S-Adenosilmetionina / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2022 Tipo del documento: Article