Oxazaborolidinone-Mediated Asymmetric Bisvinylogous Mukaiyama Aldol Reaction.
Org Lett
; 23(22): 8722-8726, 2021 11 19.
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| MEDLINE
| ID: mdl-34738464
ABSTRACT
A bisvinylogous Mukaiyama aldol reaction using oxazaborolidinones as a source of chirality was developed. This methodology allows the fast assembly of conjugated dienols by expanding the vinylogy principle by two additional carbons, and can be conducted using a readily available Lewis acid at reasonable reaction times. A broad range of aromatic and aliphatic aldehydes can be used providing access to complex building blocks for polyketide synthesis.
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2021
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