Fatty liver index and hypertension-mediated organ damage in never-treated hypertensive patients without diabetes mellitus.
J Hypertens
; 39(12): 2470-2477, 2021 12 01.
Article
en En
| MEDLINE
| ID: mdl-34738990
ABSTRACT
BACKGROUND:
We investigated whether fatty liver index (FLI), a surrogate marker of nonalcoholic fatty liver disease (NAFLD), is associated with hypertension-mediated organ damage (HMOD) in never-treated hypertensive patients without diabetes mellitus.METHODS:
We performed both clinic and ambulatory blood pressure (BP) measurements, and calculated the FLI for all participants. A FLI of no less than 60 indicates a high-risk of underlying NAFLD, whereas a FLI of less than 60 indicates lower risk. We evaluated left ventricular mass (LVM) by echocardiography, arterial stiffness by carotid--femoral pulse wave velocity (PWV), capillary rarefaction by nailfold capillaroscopy, as well as urinary albumin-to-creatinine ratio (ACR). HMOD was defined according to the categorical thresholds for each domain, except for capillary rarefaction in which case the categorization of patients was made by the median.RESULTS:
We included 146 hypertensive patients (men, 43.8%; mean age, 56.6â±â10.8âyears; BMI, 30.3â±â4.9âkg/m2; FLI, 57.2â±â27.7; office, systolic/diastolic, and 24-h BP, 153.5â±â15.8/94.7â±â9.8âmmHg, and 140.5â±â9.9/83.8â±â9âmmHg, respectively). Patients with FLI at least 60 (nâ=â76) were younger, with higher BMI and 24-h SBP, compared with patients with FLI less than 60 (nâ=â70). FLI was associated with HMOD after adjustment (LVM indexed to height, Pâ=â0.004; PWV, Pâ=â0.047; reduced capillary density, Pâ=â0.001; and logACR, Pâ=â0.003). High-risk FLI phenotype and FLI z scores increased the likelihood of any HMOD by 3.8 (95% confidence interval, 1.6-7.1) and 5.4 (95% confidence interval, 2.3-15.0) times, respectively. However, the increased number of HMOD domains has progressively stopped being determined by the FLI z scores (Pâ=â0.65).CONCLUSION:
High-risk FLI pattern was associated with various HMOD, and may re-classify never-treated hypertensive patients without diabetes mellitus into a higher cardiovascular risk level.
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus
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Hígado Graso
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Hipertensión
Límite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2021
Tipo del documento:
Article