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Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics.
He, Huamei; Baka, Tomas; Balschi, James; Motani, Alykhan S; Nguyen, Kathy K; Liu, Qingxiang; Slater, Rebecca; Rock, Brooke; Wang, Chen; Hale, Christopher; Karamanlidis, Georgios; Hartman, James J; Malik, Fady I; Reagan, Jeff D; Luptak, Ivan.
  • He H; Physiological NMR Core Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (H.H., J.B.).
  • Baka T; Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia (T.B.).
  • Balschi J; Myocardial Biology Unit, Boston University School of Medicine, MA (T.B., I.L.).
  • Motani AS; Physiological NMR Core Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (H.H., J.B.).
  • Nguyen KK; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Liu Q; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Slater R; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Rock B; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Wang C; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Hale C; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Karamanlidis G; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Hartman JJ; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
  • Malik FI; Cytokinetics Inc, South San Francisco, CA (J.J.H., F.I.M.).
  • Reagan JD; Cytokinetics Inc, South San Francisco, CA (J.J.H., F.I.M.).
  • Luptak I; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc, Thousand Oaks, CA (A.S.M., K.K.N., Q.L., R.S., B.R., C.W., C.H., G.K., J.D.R.).
Circ Heart Fail ; 15(3): e009195, 2022 03.
Article en En | MEDLINE | ID: mdl-34743528
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dobutamina / Insuficiencia Cardíaca Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dobutamina / Insuficiencia Cardíaca Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article