Hesperetin inhibits KSHV reactivation and is reversed by HIF1α overexpression.
J Gen Virol
; 102(11)2021 11.
Article
en En
| MEDLINE
| ID: mdl-34747688
ABSTRACT
Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic virus, has two life cycle modes the latent and lytic phases. KSHV lytic reactivation is important for both viral propagation and KSHV-induced tumorigenesis. The KSHV replication and transcription activator (RTA) protein is essential for lytic reactivation. Hesperetin, a citrus polyphenolic flavonoid, has antioxidant, anti-inflammatory, hypolipidemic, cardiovascular and anti-tumour effects. However, the effects of hesperetin on KSHV replication and KSHV-induced tumorigenesis have not yet been reported. Here, we report that hesperetin induces apoptotic cell death in BCBL-1 cells in a dose-dependent manner. Hesperetin inhibits KSHV reactivation and reduces the production of progeny virus from KSHV-harbouring cells. We also confirmed that HIF1α promotes the RTA transcriptional activities and lytic cycle-refractory state of KSHV-infected cells. Hesperetin suppresses HIF1α expression to inhibit KSHV lytic reactivation. These results suggest that hesperetin may represent a novel strategy for the treatment of KSHV infection and KSHV-associated lymphomas.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
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Activación Viral
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Infecciones por Herpesviridae
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Herpesvirus Humano 8
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Subunidad alfa del Factor 1 Inducible por Hipoxia
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Hesperidina
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article