Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants.
ACS Infect Dis
; 7(12): 3303-3313, 2021 12 10.
Article
en En
| MEDLINE
| ID: mdl-34752055
ABSTRACT
Multidrug-resistant bacterial infections have become a global threat. We recently disclosed that the known IKK-ß inhibitor IMD-0354 and subsequent analogues abrogate colistin resistance in several Gram-negative strains. Herein, we report the activity of a second-generation library of IMD-0354 analogues incorporating a benzimidazole moiety as an amide isostere. We identified several analogues that show increased colistin potentiation activity against Gram-negative bacteria.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Salicilanilidas
/
Colistina
Idioma:
En
Año:
2021
Tipo del documento:
Article