Closing the structure-to-function gap for LRRK2.

Tokars, Valerie; Chen, Chuyu; Parisiadou, Loukia

Tokars, Valerie; Chen, Chuyu; Parisiadou, Loukia.

Tokars V; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Chen C; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Parisiadou L; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: loukia.parisiadou@northwestern.edu.

Trends Biochem Sci ; 47(3): 187-188, 2022 03.

Article en En | MEDLINE | ID: mdl-34756665

RESUMEN

Variations in the LRRK2 gene represent one of the strongest genetic factors for Parkinson's disease (PD). It has become clear that structural knowledge of the encoded large multidomain LRRK2 protein will cast light on its biological function. The new study from Myasnikov, Zhu, et al. provides a high-resolution structure of the full-length LRRK2.

Asunto(s)

Enfermedad de Parkinson; Humanos; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/química; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/genética; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/metabolismo; Mutación; Enfermedad de Parkinson/genética; Enfermedad de Parkinson/metabolismo

Palabras clave

Parkinson's disease; cryo-EM; full-length leucine-rich repeat kinase 2 (LRRK2); high-resolution structure

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article