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Associations of serum levels of microRNA-371a-3p (M371) with risk factors for progression in nonseminomatous testicular germ cell tumours clinical stage 1.
Dieckmann, Klaus-Peter; Dumlupinar, Cansu; Radtke, Arlo; Matthies, Cord; Pichler, Renate; Paffenholz, Pia; Sommer, Jörg; Winter, Alexander; Zengerling, Friedemann; Hennig, Finja; Wülfing, Christian; Belge, Gazanfer.
  • Dieckmann KP; Department of Urology, Asklepios Klinik Altona, Hamburg, Germany.
  • Dumlupinar C; Faculty of Biology and Chemistry, University Bremen, Leobener Strasse 2/FVG, 28359, Bremen, Germany.
  • Radtke A; Mirdetect GmbH, Bremerhaven, Germany.
  • Matthies C; Department of Urology, Bundeswehrkrankenhaus Hamburg, Hamburg, Germany.
  • Pichler R; Department of Urology, University Hospital Innsbruck, Innsbruck, Austria.
  • Paffenholz P; Department of Urology, University Hospital Cologne, Cologne, Germany.
  • Sommer J; Department of Urology, St. Franziskus Krankenhaus Lohne, Lohne, Germany.
  • Winter A; Department of Urology, University Hospital Oldenburg, Oldenburg, Germany.
  • Zengerling F; Department of Urology, University Hospital Ulm, Ulm, Germany.
  • Hennig F; Faculty of Biology and Chemistry, University Bremen, Leobener Strasse 2/FVG, 28359, Bremen, Germany.
  • Wülfing C; Department of Urology, Asklepios Klinik Altona, Hamburg, Germany.
  • Belge G; Faculty of Biology and Chemistry, University Bremen, Leobener Strasse 2/FVG, 28359, Bremen, Germany. belge@uni-bremen.de.
World J Urol ; 40(2): 317-326, 2022 Feb.
Article en En | MEDLINE | ID: mdl-34775512
ABSTRACT

PURPOSE:

Lymphovascular invasion (LV1) and presence of > 50% embryonal carcinoma (> 50% EC) represent risk factors for progression in patients with clinical stage 1 (CS1) nonseminomatous (NS) testicular germ cell tumours. As serum levels of microRNA-371a-3p (M371) are capable of detecting small amounts of GCT, we evaluated if LV1 and > 50% EC are associated with M371 levels.

METHODS:

M371 serum levels were measured postoperatively in 153 NS CS1 patients and both pre- and postoperatively in 131 patients. We registered the following factors age, tumour size, LV status, > 50% EC, teratoma in primary, preoperative elevation of classical tumour markers. M371 expression was compared among subgroups. The ability of M371 to predict LV1 was calculated by receiver operating characteristics (ROC) curves. Multiple regression analysis was used to look for associations of M371 levels with other factors.

RESULTS:

Postoperatively elevated M371 levels were found in 29.4% of the patients, but were neither associated with LV status nor with > 50% EC. Likewise, relative decrease of M371 was not associated. ROC analysis of postoperative M371 levels revealed an AUC of 0.5 for the ability to predict LV1 while preoperative M371 had an AUC of 0.732. Multiple regression analysis revealed significant associations of preoperative M371 levels with LV status (p = 0.003), tumour size (p = 0.001), > 50% EC (p = 0.004), and teratoma component (p = 0.045).

CONCLUSION:

Postoperatively elevated M371 levels are not associated with risk factors for progression in NS CS1 patients. However, the significant association of preoperative M371 expression with LV1 deserves further evaluation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Neoplasias de Células Germinales y Embrionarias / MicroARNs Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Neoplasias de Células Germinales y Embrionarias / MicroARNs Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Año: 2022 Tipo del documento: Article