Downregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U).

Ge, Peipei; Gao, Mingxiao; Du, Juan; Yu, Jingbin; Zhang, Lei

Downregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U).

Ge, Peipei; Gao, Mingxiao; Du, Juan; Yu, Jingbin; Zhang, Lei.

Ge P; Department of Cardiology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, People's Republic of China.
Gao M; Department of Cardiology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, People's Republic of China.
Du J; Department of Cardiology, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
Yu J; Department of Cardiology, Zibo Central Hospital, Zibo, People's Republic of China.
Zhang L; Department of Cardiology, Zibo Central Hospital, Zibo, People's Republic of China.

Bioengineered ; 12(2): 12469-12481, 2021 12.

Article en En | MEDLINE | ID: mdl-34783632

Asunto(s)

Apoptosis/genética; Aterosclerosis/genética; Supervivencia Celular/genética; Regulación hacia Abajo/genética; Estrés del Retículo Endoplásmico/genética; Células Endoteliales de la Vena Umbilical Humana/metabolismo; MicroARNs/genética; Proteína 1 de Unión a la X-Box/genética; Animales; Autofagia/genética; Proliferación Celular/genética; Humanos; Lipoproteínas LDL/genética; Masculino; Ratones; Ratones Endogámicos C57BL; Estrés Oxidativo/genética

Palabras clave

Atherosclerosis; XBP-1; autophagy; endoplasmic reticulum stress; miR-512-3p

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Supervivencia Celular / Apoptosis / MicroARNs / Aterosclerosis / Células Endoteliales de la Vena Umbilical Humana / Estrés del Retículo Endoplásmico / Proteína 1 de Unión a la X-Box Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article

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