Crystal structure of Aedes aegypti trypsin inhibitor in complex with µ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor.

Walvekar, Varsha Ashok; Ramesh, Karthik; Jobichen, Chacko; Kannan, Muthu; Sivaraman, J; Kini, R Manjunatha; Mok, Yu Keung

Walvekar, Varsha Ashok; Ramesh, Karthik; Jobichen, Chacko; Kannan, Muthu; Sivaraman, J; Kini, R Manjunatha; Mok, Yu Keung.

Walvekar VA; Department of Biological Sciences, National University of Singapore, Singapore.
Ramesh K; Department of Biological Sciences, National University of Singapore, Singapore.
Jobichen C; Department of Biological Sciences, National University of Singapore, Singapore.
Kannan M; Department of Biological Sciences, National University of Singapore, Singapore.
Sivaraman J; Department of Biological Sciences, National University of Singapore, Singapore.
Kini RM; Department of Biological Sciences, National University of Singapore, Singapore.
Mok YK; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Protein Sci ; 31(2): 470-484, 2022 02.

Article en En | MEDLINE | ID: mdl-34800067

Asunto(s)

Aedes; Secuencia de Aminoácidos; Animales; Fibrinolisina; Inhibidores de Serina Proteinasa/química; Inhibidores de Serina Proteinasa/farmacología; Tripsina; Inhibidores de Tripsina/química; Inhibidores de Tripsina/farmacología

Palabras clave

Aedes aegypti trypsin inhibitor; Kazal-type protease inhibitor; plasmin; protein scaffold stability; surface loops of serine proteases

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aedes Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aedes Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article