Association of resting heart rate with cognitive decline and dementia in older adults: A population-based cohort study.
Alzheimers Dement
; 18(10): 1779-1787, 2022 10.
Article
en En
| MEDLINE
| ID: mdl-34859936
ABSTRACT
INTRODUCTION:
Resting heart rate (RHR) predicts future risk for cardiovascular disease (CVD). However, longitudinal studies investigating the relationship of RHR with cognitive decline are scarce.METHODS:
This population-based cohort study included 2147 participants (age≥60) in SNAC-K who were free of dementia and regularly followed from 2001-2004 to 2013-2016. RHR was assessed with electrocardiogram. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders 4th Revision criteria. Global cognitive function was assessed using Mini-Mental State Examination (MMSE). Data were analyzed using Cox and linear mixed-effects models.RESULTS:
RHR≥80 (vs. 60-69) bpm was associated with a multi-adjusted hazard ratio of 1.55 (95% confidence interval 1.06-2.27) for dementia. The association remained significant after excluding participants with prevalent and incident CVDs. Similarly, RHR≥80 bpm was associated with a multi-adjusted ß-coefficient of -0.13 (-0.21 to -0.04) for MMSE score.DISCUSSION:
Higher RHR is associated with increased risk for dementia and faster cognitive decline independent of CVDs in a general population of elderly people.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
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Demencia
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Disfunción Cognitiva
Tipo de estudio:
Etiology_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Humans
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Middle aged
Idioma:
En
Año:
2022
Tipo del documento:
Article