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Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection.
Qu, Hongke; Fan, Chunmei; Chen, Mingjian; Zhang, Xiangyan; Yan, Qijia; Wang, Yumin; Zhang, Shanshan; Gong, Zhaojian; Shi, Lei; Li, Xiayu; Liao, Qianjin; Xiang, Bo; Zhou, Ming; Guo, Can; Li, Guiyuan; Zeng, Zhaoyang; Wu, Xu; Xiong, Wei.
  • Qu H; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Fan C; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
  • Chen M; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Zhang X; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
  • Yan Q; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
  • Wang Y; Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
  • Zhang S; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
  • Gong Z; Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Shi L; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
  • Li X; Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Liao Q; Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Xiang B; Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Zhou M; Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Guo C; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Li G; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Zeng Z; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
  • Wu X; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
  • Xiong W; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
J Nanobiotechnology ; 19(1): 403, 2021 Dec 04.
Article en En | MEDLINE | ID: mdl-34863202
ABSTRACT
The cyclic signal amplification technology has been widely applied for the ultrasensitive detection of many important biomolecules, such as nucleic acids, proteins, enzymes, adenosine triphosphate (ATP), metal ions, exosome, etc. Due to their low content in the complex biological samples, traditional detection methods are insufficient to satisfy the requirements for monitoring those biomolecules. Therefore, effective and sensitive biosensors based on cyclic signal amplification technology are of great significance for the quick and simple diagnosis and treatment of diseases. Fluorescent biosensor based on cyclic signal amplification technology has become a research hotspot due to its simple operation, low cost, short time, high sensitivity and high specificity. This paper introduces several cyclic amplification methods, such as rolling circle amplification (RCA), strand displacement reactions (SDR) and enzyme-assisted amplification (EAA), and summarizes the research progress of using this technology in the detection of different biomolecules in recent years, in order to provide help for the research of more efficient and sensitive detection methods.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Nucleicos / Técnicas Biosensibles / Sondas Moleculares / Técnicas de Amplificación de Ácido Nucleico / Colorantes Fluorescentes Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Nucleicos / Técnicas Biosensibles / Sondas Moleculares / Técnicas de Amplificación de Ácido Nucleico / Colorantes Fluorescentes Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article