A C-H Functionalization Strategy Enables an Enantioselective Formal Synthesis of (-)-Aflatoxin B2.
Org Lett
; 23(24): 9393-9397, 2021 12 17.
Article
en En
| MEDLINE
| ID: mdl-34865494
ABSTRACT
An enantioselective formal synthesis of (-)-aflatoxin B2 from 4-methoxyphenylacetic acid has been achieved by an approach that produces a key carbon-carbon bond, a benzylic stereocenter, and two arene carbon-oxygen bonds in the course of three site-selective C-H functionalizations. The carbonyl-directed acetoxylation of two arene C-H bonds described herein is unprecedented in natural product synthesis and occurs under mild conditions that preserve the configuration of a sensitive benzylic stereocenter.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aflatoxina B1
Idioma:
En
Año:
2021
Tipo del documento:
Article