Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study.
ERJ Open Res
; 7(4)2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34881328
ABSTRACT
BACKGROUND:
The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.METHODS:
We studied 49â334 participants from 14 population-based cohorts in different age groups (≤10, >10-15, >15-20, >20-25â years, and overall, 5-25â years). The obstructive phenotype was defined as forced expiratory volume in 1â s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-scoreCONCLUSION:
Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
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Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Año:
2021
Tipo del documento:
Article