Dianthiamides A-E, Proline-Containing Orbitides from Dianthus chinensis.
Molecules
; 26(23)2021 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-34885850
ABSTRACT
Orbitides are plant-derived small cyclic peptides with a wide range of biological activities. Phytochemical investigation of the whole plants of Dianthus chinensis was performed with the aim to discover new bioactive orbitides. Five undescribed proline-containing orbitides, dianthiamides A-E (1-5), were isolated from a methanolic extract of Dianthus chinensis. Their structures were elucidated by extensive analysis of 1D and 2D NMR and HRESI-TOF-MS as well as ESI-MS/MS fragmentation data. The absolute configuration of the amino acid residues of compounds 1-5 was determined by Marfey's method. All compounds were tested for their cytotoxic activity, and dianthiamide A (1) exhibited weak activity against A549 cell line with IC50 value of 47.9 µM.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Prolina
/
Dianthus
/
Amidas
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article