The relationship between C-Reactive protein and mortality in adults with diabetes: Influences of demographic characteristics, lifestyle behaviors, and medications.
Nutr Metab Cardiovasc Dis
; 32(1): 176-185, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34893420
ABSTRACT
BACKGROUND AND AIMS:
This study assesses the influence of demographic, lifestyle, and medication in the association between CRP and mortality in a national sample of adults with diabetes. METHODS ANDRESULTS:
Cross-sectional study of data from 1999 to 2010 National Health and Nutrition Examination Survey (unweighted n = 3952; Weighted n = 19,064,710). Individuals were categorized as having diabetes if told by a provider they had diabetes, were taking insulin or other diabetes medications, or had a glycosylated hemoglobin A1c (HbA1c) ≥ 6.5%. CRP was classified into four categories normal (≤0.1 mg/dL); moderate risk (0.11-0.3 mg/dL); high-risk (0.31-1.0 mg/dL); very high-risk (>1.0 mg/dL). Higher risk for mortality was associated with a very high-risk of CRP (HR = 1.88 (95% CI 1.27-2.78), being a current (HR = 1.49 (95% CI 1.10-2.01) or former (HR = 1.34 (95% CI 1.03-1.73) smoker, and taking insulin (HR = 1.60 (95% CI 1.25-2.05), taking anti-hypertensives (HR = 1.50 (95% CI 1.22-1.85), and having co-morbidities such as cancer (HR = 1.32 (95% CI 1.05-1.66) and hepatitis infection (HR = 1.76 (95% CI 1.07-2.91), while taking Metformin (HR = 0.62 (95% CI 0.50-0.76) had a lower risk of mortality.CONCLUSION:
In this sample of adults with diabetes, demographic, lifestyle, and medication factors influenced the association between CRP and mortality. Interventions should focus on these factors to reduce mortality in adults with diabetes.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteína C-Reactiva
/
Diabetes Mellitus
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article