The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.

Heo, Ah Jung; Kim, Su Bin; Ji, Chang Hoon; Han, Dohyun; Lee, Su Jin; Lee, Su Hyun; Lee, Min Ju; Lee, Ji Su; Ciechanover, Aaron; Kim, Bo Yeon; Kwon, Yong Tae

Heo, Ah Jung; Kim, Su Bin; Ji, Chang Hoon; Han, Dohyun; Lee, Su Jin; Lee, Su Hyun; Lee, Min Ju; Lee, Ji Su; Ciechanover, Aaron; Kim, Bo Yeon; Kwon, Yong Tae.

Heo AJ; Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul 03080, Korea.
Kim SB; Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea.
Ji CH; AUTOTAC Bio Inc., Jongno-gu, Seoul 03077, Korea.
Han D; Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul 03080, Korea.
Lee SJ; Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea.
Lee SH; Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul 03080, Korea.
Lee MJ; Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea.
Lee JS; AUTOTAC Bio Inc., Jongno-gu, Seoul 03077, Korea.
Ciechanover A; Transdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul 03082, Korea.
Kim BY; Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul 03080, Korea.
Kwon YT; Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea.

Proc Natl Acad Sci U S A ; 118(50)2021 12 14.

Article en En | MEDLINE | ID: mdl-34893540

Asunto(s)

Proteínas Activadoras de GTPasa/metabolismo; Proteínas de Neoplasias/metabolismo; Estrés Oxidativo/fisiología; Oxígeno/metabolismo; Animales; Autofagia; Línea Celular; Proteínas Activadoras de GTPasa/genética; Regulación de la Expresión Génica; Homeostasis; Humanos; Interleucinas/genética; Interleucinas/metabolismo; Redes y Vías Metabólicas; Proteínas de Neoplasias/química; Proteínas de Neoplasias/genética; Oxidación-Reducción; Oxígeno/química

Palabras clave

Arg/N-degron pathway; Cys/N-degron pathway; N-degron pathway; oxidative stress sensor; oxygen sensor

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Estrés Oxidativo / Proteínas Activadoras de GTPasa / Proteínas de Neoplasias Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google