Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way.

En, Qiao; Zeping, Huang; Yuetang, Wang; Xu, Wang; Wei, Wang

En, Qiao; Zeping, Huang; Yuetang, Wang; Xu, Wang; Wei, Wang.

En Q; Department of Structural Heart Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China.
Zeping H; Department of Structural Heart Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China.
Yuetang W; Department of Structural Heart Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China.
Xu W; Department of Structural Heart Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China.
Wei W; Department of Structural Heart Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China. drweiwang0728@163.com.

Mol Med ; 27(1): 156, 2021 12 11.

Article en En | MEDLINE | ID: mdl-34895136

Asunto(s)

Estenosis de la Válvula Aórtica/tratamiento farmacológico; Válvula Aórtica/patología; Calcinosis/tratamiento farmacológico; Hipoglucemiantes/farmacología; Metformina/farmacología; Proteínas Quinasas Activadas por AMP/metabolismo; Válvula Aórtica/citología; Válvula Aórtica/metabolismo; Estenosis de la Válvula Aórtica/genética; Estenosis de la Válvula Aórtica/metabolismo; Calcinosis/genética; Calcinosis/metabolismo; Células Cultivadas; Humanos; FN-kappa B/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

Aortic valve interstitial cells; Apoptosis; Calcific aortic valve disease; Calcification; Metformin; PI3K/AKT signaling pathway

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Válvula Aórtica / Estenosis de la Válvula Aórtica / Calcinosis / Hipoglucemiantes / Metformina Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google