Long-term effects of adolescent sport experience, DRD2 and COMT genes, and their interaction on sport participation in adulthood.
Brain Behav
; 12(1): e2459, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34904796
ABSTRACT
BACKGROUND:
The present study investigated the joint impact of adolescent sport experience and dopamine-related genes (i.e., DRD2 and COMT genes) on sport participation in adulthood.METHODS:
Using the National Longitudinal Study of Adolescent Health (Add Health) data, the hierarchical multivariable logistic regression models for predicting sport participation in wave 3 (around 20 years of age) and wave 4 (around 30 years of age) were conducted separately by gender (male and female) and gene (DRD2 and COMT genes).RESULTS:
Adolescent sport experience significantly interacted with the number of DRD2 A1 alleles and COMT Met alleles in affecting wave 3 sport participation among male adults. The interaction between adolescent sport experience and DRD2 gene significantly affected wave 4 sport participation in opposite direction to that affected wave 3 sport participation among male participants. Among female participants, there were no significant interaction effects between dopamine-related genes and adolescent sport experience on sport participation in both wave 3 and 4.CONCLUSIONS:
Since adult sport participation is most likely to be influenced by the joint impact of environmental and genetic factors, it is important to consider gene-by-environment interactions when designing policies or programs to promote adult sport participation.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Deportes
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Catecol O-Metiltransferasa
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Receptores de Dopamina D2
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Deportes Juveniles
Tipo de estudio:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2022
Tipo del documento:
Article