Progressive nodular histiocytosis in a 9-year-old boy treated with cobimetinib.
Pediatr Dermatol
; 39(1): 115-118, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-34935192
ABSTRACT
Progressive nodular histiocytosis is a rare variant of non-Langerhans cell histiocytosis that affects the skin and mucous membranes and displays a progressive clinical course and poor response to treatment. We describe a case of severe progressive nodular histiocytosis harboring a KRAS p.G12S mutation in a 9-year-old boy, refractory to chemotherapy, who was successfully treated with the MEK inhibitor cobimetinib. This is the first report of the use of MEK inhibition for this histiocytosis subtype in a pediatric patient.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de la Piel
/
Azetidinas
/
Histiocitosis
/
Histiocitosis de Células de Langerhans
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Humans
/
Male
Idioma:
En
Año:
2022
Tipo del documento:
Article