SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis.

Panigrahi, Soumya; Goswami, Tamal; Ferrari, Brian; Antonelli, Christopher J; Bazdar, Douglas A; Gilmore, Hannah; Freeman, Michael L; Lederman, Michael M; Sieg, Scott F

Panigrahi, Soumya; Goswami, Tamal; Ferrari, Brian; Antonelli, Christopher J; Bazdar, Douglas A; Gilmore, Hannah; Freeman, Michael L; Lederman, Michael M; Sieg, Scott F.

Panigrahi S; Division of Infectious Diseases and HIV Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Goswami T; Department of Chemistry, Raiganj University, Raiganj, West-Bengal, India.
Ferrari B; Division of Infectious Diseases and HIV Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Antonelli CJ; Division of Infectious Diseases and HIV Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Bazdar DA; Division of Infectious Diseases and HIV Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Gilmore H; Department of Pathology, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Freeman ML; Division of Infectious Diseases and HIV Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Lederman MM; Division of Infectious Diseases and HIV Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Sieg SF; Division of Infectious Diseases and HIV Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.

Microbiol Spectr ; 9(3): e0073521, 2021 12 22.

Article en En | MEDLINE | ID: mdl-34935423

Asunto(s)

COVID-19/fisiopatología; Células Endoteliales/virología; SARS-CoV-2/metabolismo; Glicoproteína de la Espiga del Coronavirus/metabolismo; Células Epiteliales Alveolares/citología; Células Epiteliales Alveolares/metabolismo; Células Epiteliales Alveolares/virología; Enzima Convertidora de Angiotensina 2/química; Enzima Convertidora de Angiotensina 2/genética; Enzima Convertidora de Angiotensina 2/metabolismo; Aorta/citología; Aorta/metabolismo; Aorta/virología; Apoptosis; Bradiquinina/química; Bradiquinina/metabolismo; COVID-19/genética; COVID-19/metabolismo; COVID-19/virología; Células Endoteliales/citología; Células Endoteliales/metabolismo; Homeostasis; Humanos; Pulmón/irrigación sanguínea; Pulmón/metabolismo; Pulmón/virología; Microcirculación; Receptores de Bradiquinina/química; Receptores de Bradiquinina/genética; Receptores de Bradiquinina/metabolismo; SARS-CoV-2/genética; Glicoproteína de la Espiga del Coronavirus/química; Glicoproteína de la Espiga del Coronavirus/genética

Palabras clave

COVID-19; endothelial cells; spike protein

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Endoteliales / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / COVID-19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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