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Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
Shyam, Mousumi; Verma, Harshita; Bhattacharje, Gourab; Mukherjee, Piyali; Singh, Samsher; Kamilya, Sujit; Jalani, Pushpendu; Das, Swetarka; Dasgupta, Arunava; Mondal, Abhishake; Das, Amit Kumar; Singh, Amit; Brucoli, Federico; Bagnéris, Claire; Dickman, Rachael; Basavanakatti, Vinay N; Naresh Babu, Patibandla; Sankaran, Vadivelan; Dev, Abhimanyu; Sinha, Barij Nayan; Bhakta, Sanjib; Jayaprakash, Venkatesan.
  • Shyam M; Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
  • Verma H; Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, U.K.
  • Bhattacharje G; Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, U.K.
  • Mukherjee P; Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
  • Jalani P; Solid State and Structural Chemistry Unit, Indian Institute of Science, CV Raman Avenue, Bangalore 560012, India.
  • Das S; Microbiology Division, CSIR-Central Drug Research Institute, Sector 10 Janakipuram Extension, Sitapur Road, Lucknow 226031, India.
  • Dasgupta A; Microbiology Division, CSIR-Central Drug Research Institute, Sector 10 Janakipuram Extension, Sitapur Road, Lucknow 226031, India.
  • Mondal A; Microbiology Division, CSIR-Central Drug Research Institute, Sector 10 Janakipuram Extension, Sitapur Road, Lucknow 226031, India.
  • Das AK; Solid State and Structural Chemistry Unit, Indian Institute of Science, CV Raman Avenue, Bangalore 560012, India.
  • Singh A; Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
  • Bagnéris C; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, U.K.
  • Dickman R; Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, U.K.
  • Basavanakatti VN; Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University of London, London WC1N 1AX, U.K.
  • Naresh Babu P; Eurofins Advinus Limited, 21 & 22, Peenya Industrial area, Bengaluru 560058, India.
  • Sankaran V; Eurofins Advinus Limited, 21 & 22, Peenya Industrial area, Bengaluru 560058, India.
  • Dev A; Eurofins Advinus Limited, 21 & 22, Peenya Industrial area, Bengaluru 560058, India.
  • Sinha BN; Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
  • Bhakta S; Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
  • Jayaprakash V; Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, U.K.
J Med Chem ; 65(1): 234-256, 2022 01 13.
Article en En | MEDLINE | ID: mdl-34981940
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxazoles / Proteínas de Transporte de Membrana / Proteínas Bacterianas / Tuberculosis / Mycobacterium tuberculosis / Antituberculosos Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxazoles / Proteínas de Transporte de Membrana / Proteínas Bacterianas / Tuberculosis / Mycobacterium tuberculosis / Antituberculosos Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article