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High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM.
Li, Ke Sherry; Quinn, John G; Saabye, Matthew J; Guerrero, Jesus F Salcido; Nonomiya, Jim; Lian, Qihui; Phung, Wilson; Izrayelit, Yevgeniy; Walters, Benjamin T; Gustafson, Amy; Endres, Nicholas F; Beresini, Maureen H; Mulvihill, Melinda M.
  • Li KS; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Quinn JG; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Saabye MJ; Confluence, 4340 Duncan Avenue, Suite 400, St. Louis, Missouri 63110, United States.
  • Guerrero JFS; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Nonomiya J; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Lian Q; WuXi AppTec Co. Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Phung W; Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, California 94080, United States.
  • Izrayelit Y; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Walters BT; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Gustafson A; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Endres NF; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Beresini MH; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
  • Mulvihill MM; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.
Anal Chem ; 94(2): 1230-1239, 2022 01 18.
Article en En | MEDLINE | ID: mdl-34990117
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas p21(ras) / Descubrimiento de Drogas Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas p21(ras) / Descubrimiento de Drogas Idioma: En Año: 2022 Tipo del documento: Article