Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF-A/caveolin-1/PV-1 signaling pathway.

Locatelli, Monica; Zoja, Carlamaria; Conti, Sara; Cerullo, Domenico; Corna, Daniela; Rottoli, Daniela; Zanchi, Cristina; Tomasoni, Susanna; Remuzzi, Giuseppe; Benigni, Ariela

Locatelli, Monica; Zoja, Carlamaria; Conti, Sara; Cerullo, Domenico; Corna, Daniela; Rottoli, Daniela; Zanchi, Cristina; Tomasoni, Susanna; Remuzzi, Giuseppe; Benigni, Ariela.

Locatelli M; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Zoja C; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Conti S; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Cerullo D; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Corna D; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Rottoli D; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Zanchi C; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Tomasoni S; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Remuzzi G; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.
Benigni A; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

J Pathol ; 256(4): 468-479, 2022 04.

Article en En | MEDLINE | ID: mdl-35000230

Asunto(s)

Diabetes Mellitus Experimental; Nefropatías Diabéticas; Inhibidores del Cotransportador de Sodio-Glucosa 2; Albuminuria/tratamiento farmacológico; Albuminuria/patología; Albuminuria/prevención & control; Animales; Compuestos de Bencidrilo; Glucemia/metabolismo; Caveolina 1/metabolismo; Diabetes Mellitus Experimental/tratamiento farmacológico; Nefropatías Diabéticas/tratamiento farmacológico; Nefropatías Diabéticas/metabolismo; Nefropatías Diabéticas/prevención & control; Células Endoteliales/metabolismo; Femenino; Membrana Basal Glomerular/metabolismo; Glucósidos; Humanos; Masculino; Ratones; Transducción de Señal; Transportador 2 de Sodio-Glucosa/metabolismo; Inhibidores del Cotransportador de Sodio-Glucosa 2/farmacología; Factor A de Crecimiento Endotelial Vascular/metabolismo

Palabras clave

PV-1; SGLT2; VEGF; albuminuria; caveolin-1; empagliflozin; glomerular endothelium; podocytes; type 2 diabetic mice

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Nefropatías Diabéticas / Inhibidores del Cotransportador de Sodio-Glucosa 2 Límite: Animals / Female / Humans / Male Idioma: En Año: 2022 Tipo del documento: Article

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